Publications

  1. Sung, A.A.; Gromek,S.M.; Balunas, M.J.* Upregulation and identification of antibiotic activity of a marine-derived Streptomyces sp. via co-cultures with human pathogens. Mar. Drugs, 2017, 15, 250. These authors contributed equally. Link
  2. Juliano, S.A.; Pierce, S.; deMayo, J.A.; Balunas, M.J.; Angeles-Boza, A.M. Exploration of the innate immune system of Styela clava: Zn2+ binding enhances the antimicrobial activity of the tunicate peptide clavanin A. Biochem., 2017, 56, 1403-1414. Link
  3. deMayo, J.A.; Maas, K.R.; Klassen, J.L.; Balunas, M.J.* Draft genome sequence of Streptomyces sp. AVP053U2 isolated from Styela clava, a tunicate collected in Long Island Sound. Genome Announc., 2016, 4, e00874-16. Link
  4. Gromek, S.M.; deMayo, J.A.; Maxwell, A.T.; West, A.M.; Pavlik, C.M.; Zhao, Z.; Li, J.; Wiemer, A.J.; Zweifach, A.; Balunas, M.J.* Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity. Bioorg. Med. Chem., 2016, 24, 5183-5196. Link
  5. Gromek, S.M.; Sung, A.A.; Klassen, J.L.; Balunas, M.J.* Draft genome sequence of Streptomyces sp. strain PTY087I2 isolated from Styela canopus, a Panamanian tunicate. Genome Announc., 2016, 4, e00856-16. Link
  6. Gromek, S.M.; Suria, A.; Fullmer, M.S.; Garcia, J.L.; Gogarten, J.P.; Nyholm, S.V.*; Balunas, M.J.* Leisingera sp. JC1, a bacterial isolate from Hawaiian bobtail squid eggs, produces indigoidine and differentially inhibits vibrios. Front. Microbiol., 2016, 7, 1342. These authors contributed equally. Link
  7. Zhao, Z.; deMayo, J.A.; West, A.M.; Balunas, M.J.*; Zweifach, A.* Development of an enhanced phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis suitable for use with synthetic compound and natural product collections. J. Biomol. Screen, 2016, 21, 556-566. Link
  8. Tao, G.; Balunas, M.J.* Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research. J. Ethnopharmacol., 2016, 182, 170-180. Link
  9. Doucette, J.; Zhao, Z.; Geyer, R.J.; Barra, M.M.; Balunas, M.J.; Zweifach, A. Flow cytometry enables multiplexed measurements of genetically-encoded intramolecular FRET sensors suitable for screening. J. Biomol. Screen, 2016, 21, 535-547. Link
  10. Fenner, A.M.; Engene, N.; Spadafora, C.; Gerwick, W.H.; Balunas, M.J.* Medusamide: A Panamanian cyanobacterial depsipeptide with multiple β-amino acids. Org. Lett. 2016, 18, 352-355. Link
  11. Ku, C.-S.; Kim, B.; Pham, T.X.; Yang, Y.; Wegner, C.J.; Park, Y.-K.; Balunas, M.J.; Lee, J.-Y. Blue-green algae inhibit the development of atherosclerotic lesions in apolipoprotein E knockout mice. J. Med. Food 2015, 18, 1-8. Link
  12. Shao, C.-L.; Linington, R.G.; Balunas, M.J.; Centeno, A.; Boudreau, P.; Zhang, C.; Engene, N.; Spadafora, C.; Mutka, T.S.; Kyle, D.E.; Gerwick, L.; Wang, C.-Y.; Gerwick, W.H. Bastimolide A, a potent antimalarial polyhydroxy macrolide from the marine cyanobacterium Okeania hirsuta. J. Org. Chem. 2015, 80, 7849-7855. Link
  13. Gromek, S.M.; West, A.W.; Balunas, M.J.* Off the beathen path: Natural products from extreme environments. In Marine Biomedicine: From Beach to Bedside; Baker, B.J., Ed.; CRC Press: Boca Raton, FL, 2015; Chapter 12, pp 341-378.
  14. Gromek, S.M.; Balunas, M.J.* Natural products as exquisitely potent cytotoxic payloads for antibody-drug conjugrates. Curr. Top. Med. Chem. 2014, 14, 2822-2834. Link
  15. Carneiro, V.M.T.; Avila, C.M.; Balunas, M.J.; Gerwick, W.H.; Pilli, R.A. Coibacins A and B: Total synthesis and stereochemical revision. J. Org. Chem. 2014, 79, 630-642. Link
  16. Pavlik, C.M.; Wong, C.Y.B.; Ononye, S.; Lopez, D.D.; Engene, N.; McPhail, K.L.; Gerwick, W.H.; Balunas, M.J.* Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J. Nat. Prod. 2013, 76, 2026-2033. Link
  17. Gerwick, L.; Boudreau, P.; Choi, H.; Mascuch, S.; Villa, F.A.; Balunas, M.J.; Malloy, K.; Teasdale, M.E.; Rowley, D.C.; Gerwick, W.H. Interkingdom signaling by structurally related cyanobacterial and algal secondary metabolites. Phytochem. Rev. 2013, 12, 459-465. Link
  18. Balunas, M.J.* Attempting to solve the disconnect between humans and nature with plant-based drugs. Ecol. 2013, 94, 262-263. Link
  19. Balunas, M.J.; Grosso, M.F.; Villa, F.A.; Engene, N.; McPhail, K.L.; Tidgewell, K.; Pineda, L.M.; Gerwick, L.; Spadafora, C.; Kyle, D.E.; Gerwick, W.H. Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Org. Lett. 2012, 14, 3878-3881. Link
  20. Balunas, M.J.*; Kinghorn, A.D. Natural product compounds with aromatase inhibitory activity: An update. Planta Med. 2010, 76, 1087-1093. Link
  21. Balunas, M.J.; Linington, R.G.; Tidgewell, K.; Fenner, A.M.; Ureña, L.D.; Kyle, D.E.; Gerwick, W.H. Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. J. Nat. Prod. 2010, 73, 60-66. Link
  22. Deng, Y.; Balunas, M.J.; Kim, J.-A.; Lantvit, D.D.; Chin, Y.-W.; Chai, H..; Sugiarso, S.; Kardono, L.B.S.; Fong, H.H.S.; Pezzuto, J.M.; Swanson, S.M.; Carcache de Blanco, E.J.; Kinghorn, A.D. Bioactive 5,6-dihydro-α-pyrone derivatives from Hyptis brevipes. J. Nat. Prod. 2009, 72, 1165-1169. Link
  23. Balunas, M.J.; Su, B.; Riswan, S.; Fong, H.H.S.; Brueggemeier, R.W.; Pezzuto, J.M.; Kinghorn, A.D. Isolation and characterization of aromatase inhibitors from Brassaiopsis glomerulata (Blume) Regel. Phytochemistry Lett. 2009, 2, 29-33. Link
  24. Balunas, M.J.; Su, B.; Brueggemeier, R.W.; Kinghorn, A.D. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J. Nat. Prod. 2008, 71, 1161-1166. Link
  25. Balunas, M.J.; Su, B.; Brueggemeier, R.W.; Kinghorn, A.D. Natural products as aromatase inhibitors. Anticancer Agents Med. Chem. 2008, 8, 646-682. Link
  26. Chin, Y.-W.; Balunas, M.J.; Chai, H.B.; Kinghorn, A.D. Drug Discovery from Natural Sources. In Drug Addiction. From Basic Research to Therapy; Rapaka, R.S., Sadée, W., Eds.; Springer/AAPS Press, New York, 2008; pp 17-39. (content appeared previously in AAPS J.)
  27. Balunas, M.J.; Jones, W.P.; Chin, Y.-W.; Mi, Q.; Farnsworth, N.R.; Soejarto, D.D.; Cordell, G.A.; Swanson, S.M.; Pezzuto, J.M.; Chai, H.-B.; Kinghorn, A.D. Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project. Chem. Biodivers. 2006, 3, 897-915. Link
  28. Chin, Y.-W.; Balunas, M.J.; Chai, H.B.; Kinghorn, A.D. Drug discovery from natural sources. AAPS J. 2006, 8, E239-E253. Link
  29. Balunas, M.J.; Su, B.; Landini, S.; Brueggemeier, R.W.; Kinghorn, A.D. Interference by naturally occurring fatty acids in a non-cellular, enzyme-based aromatase bioassay. J. Nat. Prod. 2006, 69, 700-703. Link
  30. Balunas, M.J.; Kinghorn, A.D. Drug discovery from medicinal plants. Life Sci. 2005, 78, 431-441. Link
  31. Balunas, M.J.; Kimmerer, R.W. 2002. The restoration potential of goldthread, an Iroquois medicinal plant. Ecol. Restor. 2002, 20, 59-60. Link